Cellulite is primarily a problem with microcirculation that causes damage to the fat tissue under the skin that affects 80%-95% of women and 5% of men. The alternating weakening of fatty and fibrous connective tissue presents itself visually in the shape of lumps and dimples, commonly known as 'orange peel'.

Females have their subcutaneous fat structured in small chambers separated by vertical walls of tissue (above). The whole framework is irrigated by a complex vascular system of arterioles and capillaries responsible for circulation and drainage.

The failure of this microcirculation system results in leakage of liquid into the surrounding tissue. This liquid retention in the interstitial spaces also affects adipocytes which start manufacturing excess triglycerides and grow in size, becoming trapped in the connective network.

The cosmetic result of this, is an uneven distribution of fat and damaged tissue which modifies the appearance of the skin, provoking the well known lumpy "orange peel" skin. Connective tissue, including collagen and elastin, becomes increasingly damaged, eventually scarring, causing stretch marks.

Lipomelt Forté acts in two different ways: on the fat (lipolytic effect) and on the circulation (venotonic effect). Tests in vivo on human volunteers prove a drastic reduction in the thickness of subcutaneous adipose tissue when treated.

The effects of caffeine are known to have a lipolytic effect.

It blocks enzymes responsible for the destruction of AMPc, which is involved in the breakage of triglyceride in adipose tissue.It also possesses vasodilator properties, increasing blood flow.

This graph represents the amount of caffeine absorbed through the skin, comparing Lipomelt Forté with a pure caffeine formula.